Date    : 18^th November 2014

Venue : Education Centre, The Christie NHS Foundation Trust, Manchester

Course Description:

Delivered by Elaine Vickers PhD, an expert speaker on targeted cancer therapies and Director of Science Communication Ltd. This afternoon lecture provides a detailed description of the molecular pathology and classification of non-small cell lung cancer, along with information on targeted treatments in use and in development for this disease.

Learning Outcomes:

Designed for doctors, research nurses and other experienced oncology staff working in lung cancer.

Topics Include:

An Introduction to Cancer: A Disease of Many Layers:

• DNA damage: causes, types and consequences.
• Epigenetic's - the chicken or the egg?
• Cancer cells and their microenvironment - cellular diversity and cell-cell communication pathways.
• Cancer stem cells and the EMT.
• Genetic instability and intra-tumoural heterogeneity: the new enemies.

Introducing Non-small Cell Lung Cancer:

• Mechanisms of development.
• The molecular landscape of adenocarcinoma and squamous cell carcinoma.

Targeted Treatments of Non-small Cell Lung Cancer:

• Matching mutations to drugs - Strengths & Limitations.
• EGF-R targeted treatments (Gefitinib, Erlotinib, Afatatinib, Dacomitinib & Cetuximab).
• ALK inhibitors (Crizotinib & LDK378).
• VEGF-R & multi-kinase inhibitors.
• Immunotherapy (PD-1 and PDL-1 monoclonal antibodies).

Course Fees:

Delegate Fee: £60.00